complex-type mechanism-based inhibitors

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• Complex regional pain syndrome — Complex regional pain syndrome/Reflex Sympathetic Dystrophy (CRPS/RSD) Classification and external resources ICD 10 M89.0, G56.4 ICD 9 …   Wikipedia

• Development of dipeptidyl peptidase-4 inhibitors — Dipeptidyl peptidase 4 inhibitors (DPP 4 inhibitors) are enzyme inhibitors that inhibit the enzyme dipeptidyl peptidase 4 (DPP 4) and are a potent treatment for type 2 diabetes. Inhibition of the DPP 4 enzyme prolongs and enhances the activity of …   Wikipedia

• Discovery and development of integrase inhibitors — The first human immunodeficiency virus (HIV) case was reported in the 1980s. Many drugs have been discovered to treat the disease but mutations in the virus and resistance to the drugs make development difficult. Integrase is a viral enzyme that… …   Wikipedia

• Discovery and development of non-nucleoside reverse-transcriptase inhibitors — Non nucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic… …   Wikipedia

• Discovery and development of proton pump inhibitors — Proton pump inhibitors (PPIs) block the gastric Hydrogen potassium ATPase (H+,K+ ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid related diseases, including gastroesophageal reflux disease… …   Wikipedia

• Discovery and development of dual serotonin and norepinephrine reuptake inhibitors — Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs used in the treatment of major depressive disorder (MDD). SNRIs are potent inhibitors of serotonin (5 Hydroxytryptamine, 5 HT) and norepinephrine (NE,… …   Wikipedia

• Discovery and development of small molecule c-Met inhibitors — The c Met (mesenchymal epithelial transition) tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and angiogenesis.[1] c Met is a receptor tyrosine kinase,[2] which can cause a wide variety of different cancers, such… …   Wikipedia

• cGMP-specific phosphodiesterase type 5 — Phosphodiesterase 5A, cGMP specific PDB rendering based on 3BJC …   Wikipedia

• Diabetes mellitus type 2 — Classification and external resources Universal blue circle symbol for diabetes.[1] ICD 10 …   Wikipedia

• Mannan Oligosaccharide based nutritional supplements — Mannan oligosaccharide based nutritional supplements, MOS are widely used in nutrition as a natural additive. MOS has been shown to improve gastrointestinal health as well as overall health, thus improving wellbeing, energy levels and… …   Wikipedia

• Chemical biology — is a scientific discipline spanning the fields of chemistry and biology that involves the application of chemical techniques and tools, often compounds produced through synthetic chemistry, to the study and manipulation of biological systems.… …   Wikipedia